The Contribution of Adaptive Immune System Aging to Atherosclerosis – Fight Aging!

Atherosclerosis is the buildup of fatty plaques in blood vessel walls that narrow and weaken those vessels, leading to rupture and a heart attack or stroke. While it is the innate immune cells known as macrophages that are responsible for removing excess lipids from blood vessel walls, clearing up … Read more

An Update on Progress Towards Treating Atherosclerosis at Cyclarity – Fight Aging!

Today I’ll point out an interview with one of the Cyclarity Therapeutics founders, illustrative of the degree to which biotech companies are at the mercy of regulators once they arrive at the clinical stage of development. Cyclarity, formerly Underdog Pharmaceuticals, is a spin-out from the SENS Research Foundation, an … Read more

Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis – Fight Aging!

Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way that can be compensated for … Read more

Induction of Autophagy Slows High Fat Diet Induced Atherosclerosis in Mice – Fight Aging!

Atherosclerosis is the name given to the growth of fatty lesions in blood vessel walls, narrowing and weakening blood vessels, and eventually rupturing to cause a heart attack or stroke. This is the primary cause of human mortality. Many approaches have been demonstrated to slow the progression of atherosclerosis … Read more