DEL-1 Upregulation Promotes Bone Regeneration in Aged Mice – Fight Aging!

Bone is constantly remodeled throughout life. The extracellular matrix making up bone tissue is continually broken down by osteoclast cells and built up by osteoblast cells. In youth, these activities are balanced. With aging, however, the activity of osteoclast cells progressively outweighs the activity of osteoblast cells. The consequence … Read more

Senolytic CAR T Cell Therapy Improves Health in Aged Mice – Fight Aging!

Senolytic CAR T Cell Therapy Improves Health in Aged Mice To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen … Read more

Flagellin Immunization Modestly Extends Life Span After Late-Life Administration in Mice – Fight Aging!

The immune system recognizes flagellin as foreign. Flagellin is the protein found in flagellae, the whip-like structures that bacteria use to move around. Attacking and destroying these bacteria is very much a part of the immune system’s portfolio of normal activities. Thus immunization with flagellin provokes the immune system … Read more

Gene Therapy Enhances Object Recognition Memory in Young and Old Mice – Fight Aging!

Researchers here report on a gene therapy to upregulate RGS14 expression in an area of the brain associated with object recognition, showing that it enhances function in both old and young mice. Given past studies of RSG14, this is an expected result. Interestingly, increased RSG14 expression appears to produce … Read more

Induction of Autophagy Slows High Fat Diet Induced Atherosclerosis in Mice – Fight Aging!

Atherosclerosis is the name given to the growth of fatty lesions in blood vessel walls, narrowing and weakening blood vessels, and eventually rupturing to cause a heart attack or stroke. This is the primary cause of human mortality. Many approaches have been demonstrated to slow the progression of atherosclerosis … Read more

USP30 Inhibition Stops Progression of Parkinson’s Disease in Mice – Fight Aging!

USP30 Inhibition Stops Progression of Parkinson’s Disease in Mice Parkinson’s disease arises from the spread of misfolded α-synuclein proteins in the nervous system. This produces a wide array of dysfunction, but the most vulnerable cell population to this particular form of neurodegenerative pathology are domaminergenic cells. Their loss provokes … Read more