Correlations with Mortality in Levels of Proteins Secreted by Senescent Cells – Fight Aging!

Here, researchers investigate correlations between late life mortality and levels of specific proteins produced by senescent cells as a part of the senescence-associated secretory phenotype (SASP). While looking over the paper, it is worth bearing in mind that circulating levels of many of the molecules thought to be important … Read more

An Update on Kimer Med, Improving on the DRACO Antiviral Technology and Moving Towards the Clinic – Fight Aging!

The state of anti-viral therapies isn’t that great, all things considered. Technology has not yet advanced to the point at which a viral infection can be simply shut down, as is the case for near all bacterial infections. The present anti-viral drugs are either vaccines (useful!) or merely shift … Read more

Attempting to Determine Harmful versus Adaptive Changes Using Epigenetic Clock Techniques – Fight Aging!

The largest of the present challenges facing the use of epigenetic clocks to measure biological age is that there is no established causal connection between what the clock measures, meaning the methylation status of specific CpG sites on the genome, and specific aspects of the burden of age-related damage … Read more

Circulating Claudin-5 Correlates with Age and Alzheimer’s Disease – Fight Aging!

Researchers here demonstrate an association between increased claudin-5 levels in the bloodstream and age-related neurodegeneration. This is distinct from an underlying age-related decline in claudin-5 levels. The scientists do not speculate too deeply as to why this relationship might exist, but others have done so in the past. In … Read more

To What Degree is Alzheimer’s Disease a Modern Phenomenon? – Fight Aging!

Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer’s disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer’s disease is a creation of modernity, some combination of a longer life … Read more

Fight Aging! Newsletter, February 19th 2024 – Fight Aging!

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: … Read more