[ad_1] Many mechanisms are thought to contribute to the age-related decline of muscle mass and strength, but there are the usual debates over which are more important, which are the primary causes, and how they relate to one another. Little of our biochemistry is as fully understood as we might like it to be, … Read more
[ad_1] One of the interesting points made in today’s open access review paper is that there is a lack of research into the early manifestations and prevention of frailty. According to the authors, it was only recently the case that the research community established that meaningful levels of pre-frailty exist in middle-age. Further, while … Read more
[ad_1] Astrocytes Restrict Access to Amyloid-β Plaques in the Aging Brain Astrocytes react to the presence of extracellular amyloid-β aggregates in the aging brain by becoming more inflammatory and clustering around the aggregates of misfolded proteins. Researchers here show that this activity crowds out the microglia responsible for ingesting and breaking down these protein … Read more
[ad_1] In this study, researchers assessed the effects of a healthy lifestyle on mortality in older people suffering from chronic conditions of aging. As noted in similar studies, the effect size is larger than that achieved via readily available pharmaceutical strategies used to treat chronic illness, such as antihypertensive and lipid-lowering drugs. It is … Read more
[ad_1] A reduced calorie intake produces beneficial changes to metabolism, promoting autophagy and cell maintenance, among other mechanisms, improving health and leading to a modestly slowed pace of aging. Interestingly, adjusting the time of eating in order to experience longer periods of hunger while still consuming the same calorie intake produces outcomes that are … Read more
[ad_1] Cellular Senescence Disrupts Adrenal Gland Circadian Rhythm in Aging Mice This research makes for interesting reading in the context of a recent paper discussing a mismatch between brain and body circadian clocks as a contributing factor to degenerative aging. Researchers here show that an accumulation of senescent cells in the adrenal gland disrupts … Read more