Interesting Epidemiological Results for Time Restricted Feeding – Fight Aging!

[ad_1] Epidemiology is prone to difficulties that arise when attempting to interpret limited data sets, packed with information, but never quite all of the information that would be necessary to see the real story. Try to look at the health differences between people who drink and people who don’t, and the sample of those … Read more

Predicting the Order of Arrival of the First Rejuvenation Therapies – Fight Aging!

[ad_1] It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, … Read more

Fight Aging! Newsletter, March 25th 2024 – Fight Aging!

[ad_1] Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry … Read more

Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice – Fight Aging!

[ad_1] Exosomes are a class of extracellular vesicle, membrane-wrapped packages of molecules that carry a sizable fraction of the chemical communications that takes place between cells. The various types of extracellular vesicle are presently ordered in a taxonomy by their size rather than any more subtle combination of features. Those subtle features definitely exist; … Read more

TDP-43 Pathology May Extend to the Vasculature and Blood-Brain Barrier – Fight Aging!

[ad_1] TDP-43 is one of a small number of proteins that can become altered in ways that lead to the formation of solid aggregates that, directly and indirectly, cause cell dysfunction and death in the brain. In the case of TDP-43, this proteopathy contributes to amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and … Read more

The Puzzling Lack of Autoimmunity in Centenarians – Fight Aging!

[ad_1] Today’s open access paper presents an interesting discussion of the apparent lack of age-related autoimmunity in centenarians. The immune system becomes ever more dysfunctional with age, and some of that dysfunction can take the form of maladaptive changes that either (a) allow the immune system to direct attack tissues or (b) disrupt important … Read more