Reviewing the Data on Human Use of Rapamycin – Fight Aging!

[ad_1] Rapamycin and some of the later rapalog derivatives such as everolimus, all of which function via inhibition of mTOR, are arguably the best of the present crop of geroprotective drugs capable of modestly slowing aging and extending life in animal studies. The effects of rapamycin in mice are robust and repeatable, though never … Read more

Looking for Evidence of Antagonistic Pleiotropy in Human Data – Fight Aging!

[ad_1] Looking for Evidence of Antagonistic Pleiotropy in Human Data The dominant view of the evolution of aging is that it emerges from what is known as antagonistic pleiotropy, a term used to describe a mechanism that is initially helpful but later harmful. Mutations that help early life reproductive fitness will be selected even … Read more