Reviewing the Data on Human Use of Rapamycin – Fight Aging!

Rapamycin and some of the later rapalog derivatives such as everolimus, all of which function via inhibition of mTOR, are arguably the best of the present crop of geroprotective drugs capable of modestly slowing aging and extending life in animal studies. The effects of rapamycin in mice are robust … Read more

Making a Mouse that Exhibits Human Telomere Dynamics – Fight Aging!

Telomerase acts to extend telomeres, the repeated DNA sequences at the ends of chromosomes. With every cell division, some of the telomere repeats are lost. Cells with critically short telomeres become senescent or undergo programmed cell death, having reached the Hayflick limit on replication. Some cells employ telomerase to … Read more

Blunt Thoughts on Calculating the Revealed Value of Human Life – Fight Aging!

Bloodless, heartless calculations of the value of your life are constantly taking place behind the curtains that society politely draws over some of the uglier realities of the human condition. Interactions with insurance companies might be the most visible signs of these calculations, but this is the tip of … Read more

Sizes of Immune Cell Subsets Correlate with Human Mortality – Fight Aging!

The immune system is made up of many different cell types. Further, distinct populations within those types exhibit a varied range of behaviors. The molecular damage and resulting cellular dysfunction of aging produces complex changes in the immune system, as is the case for all of the complex biological … Read more

Looking for Evidence of Antagonistic Pleiotropy in Human Data – Fight Aging!

Looking for Evidence of Antagonistic Pleiotropy in Human Data The dominant view of the evolution of aging is that it emerges from what is known as antagonistic pleiotropy, a term used to describe a mechanism that is initially helpful but later harmful. Mutations that help early life reproductive fitness … Read more