Reviewing the Data on Human Use of Rapamycin – Fight Aging!

Rapamycin and some of the later rapalog derivatives such as everolimus, all of which function via inhibition of mTOR, are arguably the best of the present crop of geroprotective drugs capable of modestly slowing aging and extending life in animal studies. The effects of rapamycin in mice are robust … Read more

Reviewing the Potential for Klotho as a Basis for Therapy – Fight Aging!

Klotho is one of the few robustly longevity-associated genes discovered over the past few decades. Increased levels of the circulating α-klotho protein slows aging in mice and is associated with better late life health in humans. Additionally, more of this α-klotho appears to slow cognitive aging and also boost … Read more

Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism – Fight Aging!

Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be … Read more

Reviewing the Contributions of Circadian Rhythm Dysfunction and Dysbiosis to Blood-Brain Barrier Leakage – Fight Aging!

The blood-brain barrier is a layer of specialized cells wrapping blood vessels that pass through the brain. Only certain molecules and cells are admitted. The metabolism of the brain is thus isolated from that of the rest of the body. In particular, the immune system of the brain is … Read more