[ad_1] Researchers have implicated numerous mechanisms in the age-related loss of muscle mass and strength leading to the condition known as sarcopenia. While not everyone arrives at a diagnosis of sarcopenia, everyone is subject to the progressive deterioration of muscle tissue. One of the challenges facing attempts to understand age-related disease in detail is … Read more
[ad_1] Methionine Restriction Extends Life in Flies A sizable fraction of the benefits to health and life span resulting from the practice of calorie restriction derive from regulatory systems that are triggered by nutrient sensing mechanisms focused on specific amino acids, primarily methionine. Thus a lowered dietary methionine intake produces health benefits even when … Read more
[ad_1] In the past year or two, a great deal of effort on the part of leading researchers has gone into trying to standardize the use of a single epigenetic clock based on DNA methylation status of CpG sites on the genome. Suitable candidate universal mammalian clocks now exist. There are good reasons for … Read more
[ad_1] We launched our weekly blog in June 2014 and through our weekly blogs posts we’ve found new ways of connecting colleagues, carers and people living with dementia with each other. We’ve created a whole new kind of community that lets people share their work and passion in dementia. In this week’s blog we are … Read more
[ad_1] More and more, people are taking metformin “off-label” (in a manner not officially approved by the U.S. Food and Drug Administration [FDA]) for the treatment of prediabetes. Without intervention, many people with prediabetes will go on to develop type 2 diabetes within 5 years. However, early lifestyle interventions such as eating a healthy diet, … Read more
[ad_1] A great deal of research and development effort is now focused on finding ways to reduce the contribution of senescent cells to degenerative aging. Initiatives range from fundamental research into the biochemistry of senescent cells to clinical trials of early senolytic therapies capable of selectively destroying senescent cells. A growing burden of senescent … Read more