Assessing Epigenetic Age Acceleration as a Predictor of Age-Related Morbidity and Mortality – Fight Aging!

[ad_1] Researchers here report on an assessment of epigenetic clocks (and PhenoAge). The study is one of a fair number of attempts to quantify just how effective these aging clocks are when it comes to predicting age-related disease and death. The interesting conclusion here is that epigenetic age acceleration, … Read more

Attempting to Determine Harmful versus Adaptive Changes Using Epigenetic Clock Techniques – Fight Aging!

[ad_1] The largest of the present challenges facing the use of epigenetic clocks to measure biological age is that there is no established causal connection between what the clock measures, meaning the methylation status of specific CpG sites on the genome, and specific aspects of the burden of age-related … Read more

Advocating for Epigenetic Reprogramming as a Potential Rejuvenation Therapy – Fight Aging!

[ad_1] Partial epigenetic reprogramming emerges from the intersection of understanding how cells behave in cancerous tissue and during embryonic development. In the developing embryo there is a point at which adult germline cells convert themselves into embryonic stem cells, discarding forms of damage and dysfunction characteristic of adult cells … Read more

DNA G-Quadruplexes in Epigenetic Cell Aging – Fight Aging!

[ad_1] Researchers here describe a G-quadruplex-related mechanism operating across diverse species that contributes to epigenetic change following cell replication, leading to the Hayflick limit on replication and subsequent cell death or cell senescence. G-quadruplexes form in telomeric regions at the ends of chromosomes, and their contributions to genomic structure, … Read more

Standardization to a Single Epigenetic Clock is Much Overdue – Fight Aging!

[ad_1] In the past year or two, a great deal of effort on the part of leading researchers has gone into trying to standardize the use of a single epigenetic clock based on DNA methylation status of CpG sites on the genome. Suitable candidate universal mammalian clocks now exist. … Read more