Circulating Claudin-5 Correlates with Age and Alzheimer’s Disease – Fight Aging!

Researchers here demonstrate an association between increased claudin-5 levels in the bloodstream and age-related neurodegeneration. This is distinct from an underlying age-related decline in claudin-5 levels. The scientists do not speculate too deeply as to why this relationship might exist, but others have done so in the past. In … Read more

To What Degree is Alzheimer’s Disease a Modern Phenomenon? – Fight Aging!

Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer’s disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer’s disease is a creation of modernity, some combination of a longer life … Read more

Oxidative Stress and Cellular Senescence in Alzheimer’s Disease – Fight Aging!

Oxidative Stress and Cellular Senescence in Alzheimer’s Disease In this paper, the authors discuss the overlap between oxidative stress and growing numbers of senescent cells in the brain. Both are thought to contribute to neurodegenerative conditions such as Alzheimer’s disease. The aging of the brain is complex, a web … Read more

Bypassing Causes to Focus on Repairing Damaged Synapses in Alzheimer’s Disease – Fight Aging!

Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer’s disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems … Read more

RNA Interference as a Mechanism in Alzheimer’s Disease – Fight Aging!

RNA Interference as a Mechanism in Alzheimer’s Disease It presently costs little to assess the transcriptomic state of a cell, the amounts and sequences of various RNA transcripts produced from DNA. Thus a fair amount of research into health, disease, and cell biochemistry is focused on this complex layer … Read more

Amyloid-β Inhibits Synaptic Proteasomal Function in Alzheimer’s Disease – Fight Aging!

Cells contain many proteasomes, one portion of a broad array of repair and quality control mechanisms. The proteasome is a hollow, capped cylindrical structure made of many component proteins. It admits entry only to proteins that have been decorated with the addition of a ubiquitin molecule. Once inside the … Read more