[ad_1] The balance of microbial populations making up the gut microbiome changes with age in ways that provoke chronic inflammation, as well as reduce production of beneficial metabolites. In recent years, researchers have shown that Alzheimer’s patients exhibit a distinctly dysregulated gut microbiome in comparison to other older individuals. This raises the question of … Read more
[ad_1] Particulate Air Pollution Correlates with Risk of Alzheimer’s Disease Researchers here use data on air pollution from a single US metropolitan area to show a correlation with Alzheimer’s disease risk. Air pollution is shown to increase chronic inflammation via the interaction of particulates with lung tissue, and inflammation is an important component of … Read more
[ad_1] Researchers here demonstrate an association between increased claudin-5 levels in the bloodstream and age-related neurodegeneration. This is distinct from an underlying age-related decline in claudin-5 levels. The scientists do not speculate too deeply as to why this relationship might exist, but others have done so in the past. In short, claudin-5 is an … Read more
[ad_1] Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer’s disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer’s disease is a creation of modernity, some combination of a longer life expectancy for a greater … Read more
[ad_1] Oxidative Stress and Cellular Senescence in Alzheimer’s Disease In this paper, the authors discuss the overlap between oxidative stress and growing numbers of senescent cells in the brain. Both are thought to contribute to neurodegenerative conditions such as Alzheimer’s disease. The aging of the brain is complex, a web of interacting processes, causes, … Read more
[ad_1] Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer’s disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, … Read more