Assessing Epigenetic Age Acceleration as a Predictor of Age-Related Morbidity and Mortality – Fight Aging!

[ad_1] Researchers here report on an assessment of epigenetic clocks (and PhenoAge). The study is one of a fair number of attempts to quantify just how effective these aging clocks are when it comes to predicting age-related disease and death. The interesting conclusion here is that epigenetic age acceleration, … Read more

Circulating Claudin-5 Correlates with Age and Alzheimer’s Disease – Fight Aging!

[ad_1] Researchers here demonstrate an association between increased claudin-5 levels in the bloodstream and age-related neurodegeneration. This is distinct from an underlying age-related decline in claudin-5 levels. The scientists do not speculate too deeply as to why this relationship might exist, but others have done so in the past. … Read more

Monocyte Population Differences with Age Following Bone Fracture – Fight Aging!

[ad_1] The innate immune system is involved in tissue maintenance and regeneration. That includes populations of monocytes, circulating innate immune cells in the bloodstream that enter damaged tissue to become macrophages. Monocytes are somewhat easier to catalog and study than is the case for macrophages. The former can be … Read more

Chronological Age is Not a Good Component of Patient Risk Assessment – Fight Aging!

[ad_1] Chronological age is embedded in a great many standardized, widely-used protocols for patient risk assessment. Age-related diseases are, after all, age-related, and this use of chronological age has long seemed a reasonable choice. That said, we are now moving into an era in which novel means of measuring … Read more