Commentary on Gaps in the Knowledge of Aging – Fight Aging!

[ad_1] There are any number of sizable gaps in the understanding of how aging progresses at the detail level, which processes are more or less important, the direct of causation for many different interactions, and so forth. Aging is very complex because a living organism is very complex. Even simply causes produce complex outcomes … Read more

LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy – Fight Aging!

[ad_1] The primary focus of the Longevity Escape Velocity (LEV) Foundation is to demonstrate that therapies based on the repair of forms of underlying molecular damage that cause aging can be combined to produce greater rejuvenation. Research of recent years has demonstrated quite comprehensively that the alternative strategy for treating aging, to manipulate metabolism … Read more

Fight Aging! Newsletter, January 22nd 2024 – Fight Aging!

[ad_1] Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry … Read more

Genetic Associations with Longevity are Stronger in Women – Fight Aging!

[ad_1] It seems likely that researchers will still be debating the well-established difference in life expectancy between men and women long after the first rejuvenation therapies make that difference irrelevant. Of the many possible contributing causes, it at least seems reasonable to rule out the sociological explanations based on behavioral differences, given that sex … Read more

DNA G-Quadruplexes in Epigenetic Cell Aging – Fight Aging!

[ad_1] Researchers here describe a G-quadruplex-related mechanism operating across diverse species that contributes to epigenetic change following cell replication, leading to the Hayflick limit on replication and subsequent cell death or cell senescence. G-quadruplexes form in telomeric regions at the ends of chromosomes, and their contributions to genomic structure, epigenetics, and aging are far … Read more

Flagellin Immunization Modestly Extends Life Span After Late-Life Administration in Mice – Fight Aging!

[ad_1] The immune system recognizes flagellin as foreign. Flagellin is the protein found in flagellae, the whip-like structures that bacteria use to move around. Attacking and destroying these bacteria is very much a part of the immune system’s portfolio of normal activities. Thus immunization with flagellin provokes the immune system into greater activity and … Read more