[ad_1] The largest of the present challenges facing the use of epigenetic clocks to measure biological age is that there is no established causal connection between what the clock measures, meaning the methylation status of specific CpG sites on the genome, and specific aspects of the burden of age-related damage and dysfunction; e.g. which … Read more
[ad_1] Researchers here demonstrate an association between increased claudin-5 levels in the bloodstream and age-related neurodegeneration. This is distinct from an underlying age-related decline in claudin-5 levels. The scientists do not speculate too deeply as to why this relationship might exist, but others have done so in the past. In short, claudin-5 is an … Read more
[ad_1] Here find an interesting commentary on what might be gleaned of the prevalence of Alzheimer’s disease in antiquity from the body of ancient writings on the topic of aging, memory, and health. The consensus is that Alzheimer’s disease is a creation of modernity, some combination of a longer life expectancy for a greater … Read more
[ad_1] Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry … Read more
[ad_1] Today’s open access paper outlines results from an epidemiological study, and is a fairly standard examination of the relationship between being overweight and outcomes such as increased risk of age-related disease and mortality. Being a modern study, it uses waist circumference rather than body mass index, as the most problematic fat tissue held … Read more
[ad_1] It is now commonplace for patients to undergo first generation stem cell therapy where the transplanted cells (which may or may not actually be stem cells) are derived from fat tissue. These therapies clearly produce some degree of benefit, primarily suppression of inflammation. There is a high degree of variability of outcomes between … Read more