[ad_1] Today’s open access review paper goes back to the basics on aging and cancer, a first principles consideration of whether or not the evidence shows that we should think of cancer as a distinct process from aging. It is certainly the case that while cancer incidence increases with age, it doesn’t keep on … Read more
[ad_1] Macrophages are innate immune cells of the body, microglia the analogous innate immune cells of the central nervous system. All microglia and most macrophages depend on the function of colony stimulating factor 1 receptor (CSF1R); if this protein or its function are suppressed, the cells die. Following clearance of microglia and macrophages, the … Read more
[ad_1] Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry … Read more
[ad_1] Intervertebral disc degeneration is a feature of aging, and injury can produce further challenges. A range of approaches have been assessed to enhance the regenerative capacity of disc tissue, useful not just after injury, but also to reverse some of the declines in disc structure and function produced by aging. Stem cell therapies … Read more
[ad_1] Senescent cells accumulate with age as the immune system falters in its ability to clear these cells in a timely fashion. Senolytic therapies selectively destroy some fraction of senescent cells, and first generation senolytic drugs have been demonstrated to rapidly and impressively reverse age-related disease and extend life in mice. The best of … Read more
[ad_1] Exercise is known to improve cognitive function and neurogenesis, the process by which new neurons are created by neural stem cells and then mature to integrate into existing neural networks. Neurogenesis is best studied in the hippocampus, where it is necessary for learning and memory function to take place. It is also likely … Read more