[ad_1] Many mechanisms are thought to contribute to the age-related decline of muscle mass and strength, but there are the usual debates over which are more important, which are the primary causes, and how they relate to one another. Little of our biochemistry is as fully understood as we might like it to be, … Read more
[ad_1] A reduced calorie intake produces beneficial changes to metabolism, promoting autophagy and cell maintenance, among other mechanisms, improving health and leading to a modestly slowed pace of aging. Interestingly, adjusting the time of eating in order to experience longer periods of hunger while still consuming the same calorie intake produces outcomes that are … Read more
[ad_1] Cells contain many proteasomes, one portion of a broad array of repair and quality control mechanisms. The proteasome is a hollow, capped cylindrical structure made of many component proteins. It admits entry only to proteins that have been decorated with the addition of a ubiquitin molecule. Once inside the proteasome’s central chamber, the … Read more
[ad_1] Cells maintain themselves against damage and stress via a range of maintenance processes. These include autophagy, in which proteins and structures are transported to the lysosome to be broken down by enzymes, and the ubiquitin-proteasome system, in which specific proteins are dismantled in the proteasome, among others. It is well demonstrated that upregulation … Read more
[ad_1] The gut microbiome changes with age. Pro-inflammatory microbial populations grow in size at the expense of populations that produce beneficial metabolites. As researchers produce increasingly large databases of the composition of the gut microbiome across ages and populations, they are also mapping a growing number of specific connections between microbial species and aspects … Read more