Amyloid-β Inhibits Synaptic Proteasomal Function in Alzheimer’s Disease – Fight Aging!

Cells contain many proteasomes, one portion of a broad array of repair and quality control mechanisms. The proteasome is a hollow, capped cylindrical structure made of many component proteins. It admits entry only to proteins that have been decorated with the addition of a ubiquitin molecule. Once inside the … Read more

NRF1 is Neuroprotective via Proteasomal Function – Fight Aging!

Cells maintain themselves against damage and stress via a range of maintenance processes. These include autophagy, in which proteins and structures are transported to the lysosome to be broken down by enzymes, and the ubiquitin-proteasome system, in which specific proteins are dismantled in the proteasome, among others. It is … Read more

Changes in the Gut Microbiome Correlate with Aging and Renal Function – Fight Aging!

The gut microbiome changes with age. Pro-inflammatory microbial populations grow in size at the expense of populations that produce beneficial metabolites. As researchers produce increasingly large databases of the composition of the gut microbiome across ages and populations, they are also mapping a growing number of specific connections between … Read more