[ad_1] Angiogenesis, the complex set of processes by which new blood vessels are produced, becomes less efficient with advancing age. One important consequence is a loss of capillary density, which has a range of detrimental effects on tissue function, particularly in energy-hungry tissues such as the brain and muscle. Regeneration from injury is also … Read more
[ad_1] The composition of the gut microbiome influences health and aging. In addition to variations between individuals, the relative abundances of different microbial populations making up the gut microbiome change with age in ways that contribute to chronic inflammation and the loss of useful metabolite production. Researchers here demonstrate that it is possible to … Read more
[ad_1] Epigenetic Change with Age in Mice is Not Linear Epigenetic marks such as DNA methylation control expression of genes and cell behavior. They change with age, a reflection of the processes of damage and dysfunction that occur with age. Researchers here focus on DNA methylation in one organ in mice to demonstrate that … Read more
[ad_1] The Pace of Aging biomarker emerged from analysis of the Dunedin Study data. It is analogous to epigenetic clocks or phenotypic age, in that it is produced by a machine learning approach, working backwards from a large database of parameters and their changes with age in the study population. Instead of being an … Read more
[ad_1] Atherosclerosis is the buildup of fatty plaques in blood vessel walls that narrow and weaken those vessels, leading to rupture and a heart attack or stroke. While it is the innate immune cells known as macrophages that are responsible for removing excess lipids from blood vessel walls, clearing up the damage that leads … Read more
[ad_1] Klotho is one of the few longevity-associated genes shown to work in both directions; lower expression shortens life span in animal studies, while increased expression modestly slows aging. Despite several decades of research, scientists have yet to reach a full understanding of how klotho influences life span. The klotho gene produces a transmembrane … Read more