[ad_1] The innate immune system is involved in tissue maintenance and regeneration. That includes populations of monocytes, circulating innate immune cells in the bloodstream that enter damaged tissue to become macrophages. Monocytes are somewhat easier to catalog and study than is the case for macrophages. The former can be found in a blood sample, … Read more
[ad_1] Rapamycin and some of the later rapalog derivatives such as everolimus, all of which function via inhibition of mTOR, are arguably the best of the present crop of geroprotective drugs capable of modestly slowing aging and extending life in animal studies. The effects of rapamycin in mice are robust and repeatable, though never … Read more
[ad_1] Oxidative Stress and Cellular Senescence in Alzheimer’s Disease In this paper, the authors discuss the overlap between oxidative stress and growing numbers of senescent cells in the brain. Both are thought to contribute to neurodegenerative conditions such as Alzheimer’s disease. The aging of the brain is complex, a web of interacting processes, causes, … Read more
[ad_1] Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer’s disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, … Read more
[ad_1] Frailty is an inevitability for everyone on some timescale, given the present state of medical technology. It is not, however, an inevitability for early old age. It can be postponed for decades. Further, if someone becomes frail in earlier old age, that frailty may be reversible given sufficient effort put into treatment and … Read more
[ad_1] Further Assessing the Effects of Air Pollution on Mortality There is ample evidence to show that air pollution correlates with increased mortality, and a number of natural experiments have allowed researchers to compare populations with similar socioeconomic status and different levels of air pollution, in order to demonstrate that effects do not result … Read more